Sermorelin

Sermorelin is a synthetic growth-hormone–releasing hormone (GHRH 1–29) analog that binds pituitary GHRH receptors (GHRHR) to provoke physiologic, pulsatile GH release and downstream increases in IGF-1. In the U.S., sermorelin was previously marketed as Geref®/Geref Diagnostic® for evaluating pituitary GH reserve; it is not FDA-approved for chronic treatment of growth disorders or obesity and branded drug was discontinued for non-safety/commercial reasons. Compounded products are used off-label in some settings.